Background and Objectives To determine the efficacy and safety of a novel 1,927 nm fractionalthulium laser system in treating moderate-to-severe melasma in Koreansubjects. Materials and Methods This study is a retrospective chart and photographic review of 68 Koreanwomen (Fitzpatrick skin type III-IV, mean age of 43.9 yr) with a clinicaldiagnosis of melasma treated with a novel 1,927 nm fractional thulium lasersystem. Two independent and blinded investigators evaluated the MelasmaArea Severity Index (MASI) scores for each patient, based on clinicalphotography. Results A total of 204 consecutive treatment sessions in 68 patients wereincluded in the analysis. The mean MASI scores decreased from 10.7 ±5.3 to 7.6 ± 4.6, at 2 weeks after 3 consecutive laser treatments(p=0.0001). The subjective assessment of patients revealed that 33 out of68 subjects were successful in clearing more than 50% of their melasma.Mild and transient postinflammatory hyperpigmentation developed inthree patients. Two patients experienced worsening of pre-existing acne.Sixty patients were successfully followed-up (mean 4.1 months), and therecurrence rate was 21.7%. Conclusion The novel 1,927 nm fractional thulium laser resurfacing appears to besafe and effective for melasma treatment in the Korean population.
Hair graying is a common age-related hair change with tremendoussocial and cosmetic concerns among aged individuals. Manymechanisms contribute to hair graying, such as defective melanocytestem cell renewal, melanocyte apoptosis, and melanocyte migrationdefects. Accumulation of oxidative stress has been regarded as a keyfactor influencing these processes. However, currently, there is nostandard treatment for reversing hair graying. Herein, we report ourobservation of improvement of hair graying in a patient with male patternhair loss during combined treatment with 1,927-nm fractionated thuliumlaser energy and intra-perifollicular polydeoxyribonucleotide injections.The patient showed increased numbers of pigmented hair follicles andclinical improvement in hair graying after 12 sessions of combinedtreatment. Accordingly, we suggest that the combined treatmentdescribed in this report may be a promising therapeutic method fortreating hair graying.
Café-au-lait macules are a benign cutaneous pigmentary disorder withvariable responses to laser treatment. We treated a 21-year-old femalewith recurred café-au-lait macules on the thigh using a combination offrequency-doubled Q-switched neodymium-doped yttrium aluminumgarnet laser followed by 10 sessions of fractional laser, via a novel 1,927nm fractional thulium laser. At the 11-month follow-up after the lasttreatment, no foci of re-pigmentation were found. We suggest thatfractional thulium laser resurfacing, combined with conventionalQ-switched laser treatment, can be used as a safe and effective adjuvanttherapy in patients with treatment-resistant café-au-lait macules.
Background and Objectives Intra-perifollicular polydeoxyribonucleotide (PDRN) injections result in clinical improvements in hair thickness and density in patients with pattern hair loss (PHL). The objective of this study is to evaluate the efficacy of combined treatment with a 1,927-nm fractionated thulium laser and PDRN injections for treatment of PHL. Materials and Methods We compared clinical outcomes in eight PHL patients treated with 12 sessions of combined treatment with thulium laser and PDRN injections to those in another eight PHL patients treated with 12 sessions of mesotherapy and PDRN injections. Results One week after the final treatment session, patients treated with the thulium laser and PDRN showed clinical improvements in mean hair counts (20.4 ± 15.7%; p=0.005) and mean hair thickness (53.1 ± 31.1%; p <0.001), compared to baseline values. Patients treated with mesotherapy and PDRN also showed clinical improvements in mean hair counts (9.7 ± 7.4%; p=0.007) and mean hair thickness (16.1 ± 25%; p>0.05). Further statistical analysis showed that combined treatment with the thulium laser and PDRN injections resulted in greater improvement in hair thickness (p=0.029) than combined application of mesotherapy and PDRN, but not in hair counts (p>0.05). Conclusion Use of thulium laser energy in combination with PDRN injections for treatment of PHL results in remarkable improvements in hair thickness and density.